Hotel Hemus is located in Lozenets district, one of Sofia's major business districts housing the offices of many Bulgarian and international companies. The hotel stands at the bottom of Lozenets hill and faces the city center.

The National Palace of Culture and Hotel Hilton are nearby. The South Park as well as Sofia's major government, business, entertainment and cultural sites are within walking distance. On the other side of Lozenets hill is Sofia Land, one of the largest entertainment parks on the Balkan Peninsula.

Hotel Hemus is 10 minutes away from the Central Railway Station, Central Bus Station, Presidential building and Alexander Nevski Cathedral, and 15 minutes away from Sofia International Airport.